Skip to main content
MNF predictions and odds for the MNF: Lions vs 49ers matchup

In a relatively meaningless game for both teams, we could have taken a little risk with our predictions for anytime scorers ahead of the Monday Night Football matchup between the Detroit Lions and San Francisco 49ers. Instead, however, I'll trust a couple of starting players to find the end zone and offer a strategy on how I'll deal with the players with higher touchdown odds.

The Lions will travel to San Francisco in Week 17 to face the 49ers before their biggest game of the regular season, as they will meet the Minnesota Vikings next week to determine who will wear the NFC North crown.

Because of this, many refrain from betting on the touchdowns and overs associated with the Lions starters. However, I believe their alpha wideout will score before he potentially leaves the game as part of our NFL Week 17 predictions.

On the other hand, a certain 49ers receiver looked rejuvenated last week - too little, too late - and I'll back him to find the end zone on Monday night when the game kicks off at 8:15 p.m. ET (ESPN) from Levi's Stadium.

Monday Night Football Predictions: Lions vs. 49ers

Prediction on the Lions' top touchdown scorer: Amon-Ra St. Brown, WR ⭐⭐⭐⭐
Best odds: +100 on FanDuel | Estimated odds: 50%.

Sure, it's risky because we may only have two or three quarters to make this bet. However, I still like St. Brown's chances of scoring on Monday night, and these +100 odds represent decent value.

St. Brown's TD prediction is one of the best for receivers this week at 0.58, though this prediction also assumes he'll get his usual workload.

The problem with that is we don't know what head coach Dan Campbell, a contender for NFL Coach of the Year, will do in this game with backup quarterbacks Allen Robinson, Tom Kennedy or No. 2 running back Craig Reynolds.

The Lions have had a slew of injuries this year, so you can expect him to give the starting lineup players a rest in this somewhat meaningless game. However, this is a team that never says die.

So I'd rather back St. Brown before kickoff and then look for live betting opportunities depending on how the game plays out. Sure, you can get +2600 on Robinson scoring right now, but he also might not score a single point.

I always prefer to have more information at my disposal rather than rushing to the best number too early based on mere guesswork.

Prediction on the 49ers' top touchdown scorer: Deebo Samuel, WR ⭐⭐⭐⭐
Best odds: +175 on DraftKings | Estimated probability: 36.36%


It's been 16 weeks, but the 49ers dual-threat receiver scored his first 20 points of the season in a PPR fantasy half against the Miami Dolphins, turning seven picks into 96 yards and adding another 25 on the ground. But most importantly, he got into the end zone for the first time since Week 6.

It was only his third TD of the season, but it gives us hope that Samuel can finish the season strong. The projected TD on receptions is 0.34, but since running back Isaac Guerendo is injured, Samuel's projected TD on the run is 0.14 after five picks last week.

So with a projection of 0.48, we get a very solid odds associated with a 36 percent implied probability that he will score.

Expert predictions for Monday Night Football
Lions vs. 49ers prediction
Lions vs. 49ers betting odds on MNF
Lions vs. 49ers parlay picks

Related Articles

Who will win Super Bowl 2025: Everything you need to know about the odds on the Chiefs and Eagles winning the game

Who will win Super Bowl 2025: Everything you need to know about the odds on the Chiefs and Eagles winning the game

The Chiefs vs. Eagles for Super Bowl 59 is just 10 days away and the betting market is already shaping up. The action kicks off at Caesars Superdome a...

Read more
Chiefs vs. Eagles: What's changed for both sides ahead of Super Bowl 2025?

Chiefs vs. Eagles: What's changed for both sides ahead of Super Bowl 2025?

Rarely does a rematch for this year's Super Bowl happen for just the 10th time in NFL history when the Kansas City Chiefs meet the Philadelphia Eagles...

Read more
Prediction for Chiefs vs. Eagles, Super Bowl odds and betting odds today: Can Philadelphia beat Kansas City?

Prediction for Chiefs vs. Eagles, Super Bowl odds and betting odds today: Can Philadelphia beat Kansas City?

A Super Bowl without the Chiefs would be like Groundhog Day without Phil Punxsutawney.Patrick Mahomes will complete his eighth NFL season when Super B...

Read more
Super Bowl Betting Strategies: How to approach betting on Chiefs vs. Eagles

Super Bowl Betting Strategies: How to approach betting on Chiefs vs. Eagles

With so many betting options ahead of the Big Game, it never hurts to develop or review some Super Bowl betting strategies. Before betting on the Chie...

Read more
New Orleans' Super Bowl history ahead of Chiefs vs. Eagles: Matchup results and scores

New Orleans' Super Bowl history ahead of Chiefs vs. Eagles: Matchup results and scores

NFL fans will gather in New Orleans at the familiar site of the “Big Game” for Super Bowl 2025 featuring the Kansas City Chiefs and Philadelphia E...

Read more
Kentucky vs Tennessee game predictions, odds and previews: Best Predictions for January 28th

Kentucky vs Tennessee game predictions, odds and previews: Best Predictions for January 28th

Two teams that have been upset by Vanderbilt in recent days will meet tonight at 7 PM ET (ESPN) at the Food City Center in Knoxville, Tennessee when K...

Read more